PRDM1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PRDM1 in A-549 cell lysate with PRDM1 polyclonal antibody (Cat # PAB13233) at (A) 0.5 and (B) 1 ug/mL .
Immunofluorescence
Immunofluorescence of PRDM1 in mouse lung tissue with PRDM1 polyclonal antibody (Cat # PAB13233) at 20 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRDM1.
Immunogen
A synthetic peptide corresponding to 14 amino acids near C-terminus of human PRDM1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (0.5-1 ug/mL)
Immunofluorescence (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PRDM1 in A-549 cell lysate with PRDM1 polyclonal antibody (Cat # PAB13233) at (A) 0.5 and (B) 1 ug/mL .Immunofluorescence
Immunofluorescence of PRDM1 in mouse lung tissue with PRDM1 polyclonal antibody (Cat # PAB13233) at 20 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRDM1
Entrez GeneID
639Protein Accession#
NP_001189Gene Name
PRDM1
Gene Alias
BLIMP1, MGC118922, MGC118923, MGC118924, MGC118925, PRDI-BF1
Gene Description
PR domain containing 1, with ZNF domain
Omim ID
603423Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq
Other Designations
B-lymphocyte-induced maturation protein 1|OTTHUMP00000016918|PR-domain zinc finger protein 1|PRDI-binding factor-1|beta-interferon gene positive-regulatory domain I binding factor|positive regulatory domain I-binding factor 1
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Interactome
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Disease
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Publication Reference
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Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.
Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K.
Nature Immunology 2006 May; 7(5):457.
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Plasma cell differentiation requires the transcription factor XBP-1.
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH.
Nature 2001 Jul; 412(6844):300.
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Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo.
Angelin-Duclos C, Cattoretti G, Lin KI, Calame K.
The Journal of Immunology 2000 Nov; 165(10):5462.
Application：IF, IHC-P, IP-WB, WB-Ce, Human, Mouse, Spleen, Tonsil.
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Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.
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