IL23A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of IL23A in Raji lysate with IL23A polyclonal antibody (Cat # PAB13197) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.
Immunocytochemistry
Immunocytochemistry of IL23A in Raji cells with IL23A polyclonal antibody (Cat # PAB13197) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IL23A.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human IL23A.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IL23A in Raji lysate with IL23A polyclonal antibody (Cat # PAB13197) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.Immunocytochemistry
Immunocytochemistry of IL23A in Raji cells with IL23A polyclonal antibody (Cat # PAB13197) at 10 ug/mL . -
Gene Info — IL23A
Entrez GeneID
51561Protein Accession#
AAH66268Gene Name
IL23A
Gene Alias
IL-23, IL-23A, IL23P19, MGC79388, P19, SGRF
Gene Description
interleukin 23, alpha subunit p19
Omim ID
605580Gene Ontology
HyperlinkGene Summary
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq
Other Designations
JKA3 induced upon T-cell activation|interleukin 23 p19 subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
Hunter CA.
Nature Reviews. Immunology 2005 Jul; 5(7):521.
Application：ELISA, Human, Mouse, T cells.
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Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.
Pirhonen J, Matikainen S, Julkunen I.
Journal of Immunology 2002 Nov; 169(10):5673.
Application：WB-Ce, Human, Human macrophages.
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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA.
Immunity 2000 Nov; 13(5):715.
Application：WB-Ce, WB-Tr, Human, Mouse, 293T, DCs.
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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
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