CASP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP1.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human CASP1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5 ug/mL)
Immunohistochemistry (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CASP1 in human heart tissue lysate with CASP1 polyclonal antibody (Cat # PAB13134) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human heart tissue using CASP1 polyclonal antibody (Cat # PAB13134) at 2 ug/mL . -
Gene Info — CASP1
Entrez GeneID
834Protein Accession#
NP_150634Gene Name
CASP1
Gene Alias
ICE, IL1BC, P45
Gene Description
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Omim ID
147678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
CASP1 nirs variant 1|IL1B-convertase|caspase 1|caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)|interleukin 1-B converting enzyme|interleukin 1-beta convertase
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Interactome
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Pathway
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Disease
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Publication Reference
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon F, Tschopp J.
Cell 2004 May; 117(5):561.
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Interleukin-18.
Gracie JA, Robertson SE, McInnes IB.
Journal of Leukocyte Biology 2003 Feb; 73(2):213.
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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA.
Science 1995 Mar; 267(5206):2000.
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
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