RIPK2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of RIPK2 in A-431 (A) and K-562 (K) whole cell lysate with RIPK2 polyclonal antibody (Cat # PAB13078) at 1 : 1000 dilution.
Immunocytochemistry
Immunocytochemistry of RIPK2 in A-431 cells with RIPK2 polyclonal antibody (Cat # PAB13078) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RIPK2.
Immunogen
A synthetic peptide corresponding to N-terminus of human RIPK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
An approximately 60 KDa band can be detected.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RIPK2 in A-431 (A) and K-562 (K) whole cell lysate with RIPK2 polyclonal antibody (Cat # PAB13078) at 1 : 1000 dilution.Immunocytochemistry
Immunocytochemistry of RIPK2 in A-431 cells with RIPK2 polyclonal antibody (Cat # PAB13078) at 10 ug/mL . -
Gene Info — RIPK2
Entrez GeneID
8767Protein Accession#
O43353Gene Name
RIPK2
Gene Alias
CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Gene Description
receptor-interacting serine-threonine kinase 2
Omim ID
603455Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq
Other Designations
CARD-carrying kinase|CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase|growth-inhibiting gene 30|receptor interacting protein 2|receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J.
Current Biology 1998 Jul; 8(15):885.
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RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
McCarthy JV, Ni J, Dixit VM.
The Journal of Biological Chemistry 1998 Jul; 273(27):16968.
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RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.
Inohara N, del Peso L, Koseki T, Chen S, Núñez G.
The Journal of Biological Chemistry 1998 May; 273(20):12296.
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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
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