MAP3K7 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K7.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human MAP3K7.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of MAP3K7 in rat thymus tissue lysate with MAP3K7 polyclonal antibody (Cat # PAB12934) at (A) 1, (B) 2, and (C) 4 ug/mL . -
Gene Info — MAP3K7
Entrez GeneID
6885Protein Accession#
BAA25025Gene Name
MAP3K7
Gene Alias
TAK1, TGF1a
Gene Description
mitogen-activated protein kinase kinase kinase 7
Omim ID
602614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000016870|OTTHUMP00000016871|OTTHUMP00000016872|OTTHUMP00000016873|TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Toll-like receptor signalling.
Akira S, Takeda K.
Nature Reviews. Immunology 2004 Jul; 4(7):499.
-
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X.
Molecular and Cellular Biology 2002 Oct; 22(20):7158.
Application:IP, WB-Tr, Human, HEK 293 cells.
-
TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages.
Irie T, Muta T, Takeshige K.
FEBS Letters 2000 Feb; 467(2-3):160.
Application:WB-Ce, Mouse, RAW 264.7.
-
Toll-like receptor signalling.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com