SOCS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
Immunogen
A synthetic peptide corresponding to C-terminus of human and mouse SOCS1.
Host
Rabbit
Theoretical MW (kDa)
24
Reactivity
Human, Mouse
Specificity
This antibody recognizes ~24 KDa of SOCS1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
The tissue/cell lysate derived from mouse liver (Lane 1), mouse muscle (Lane 2) and MCF-7 (Lane 3) were immunoprobed by SOCS1 polyclonal antibody (Cat # PAB12778) at 1 : 500. An immunoreactive band is observed around ~24kDa.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SOCS1
Entrez GeneID
8651Gene Name
SOCS1
Gene Alias
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Gene Description
suppressor of cytokine signaling 1
Omim ID
603597Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
Other Designations
JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
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Gene Info — Socs1
Entrez GeneID
12703Gene Name
Socs1
Gene Alias
Cish1, Cish7, JAB, SOCS-1, SSI-1
Gene Description
suppressor of cytokine signaling 1
Gene Ontology
HyperlinkOther Designations
JAK-binding protein|JAK2-binding protein|STAT-induced STAT inhibitor 1|cytokine inducible SH2-containing protein 1|cytokine inducible SH2-containing protein 7
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Interactome
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Pathway
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Disease
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Publication Reference
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IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia.
Qin H, Wilson CA, Lee SJ, Benveniste EN.
FASEB Journal 2006 May; 20(7):985.
Application:WB, Mouse, EOC13 cells, Murine primary microglia, Raw 264.7 cells.
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IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia.
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