The tissue lysates derived from hypoxic mouse brain were immunoblotted by NF1 (phospho S2741) polyclonal antibody (Cat # PAB12637) at 1 : 1000.
Dot Blot (Peptide)
Dot Blot : 1 ug peptide was blot onto NC membrane. A : NF1 (pS2741). B : NF1 (Non-phospho). C : Non-related phospho-specific phophopeptide. Followed were blotted at a 1 : 1000 dilution by : 1. NF1 (phospho S2741) polyclonal antibody (Cat # PAB12637). 2. NF1 polyclonal antibody (Cat # PAB12636).
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq