CSF1R (phospho Y723) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The whole cell lysate derived from m-CSF stimulated LNCaP was immunoblotted by CSF1R (phospho Y723) polyclonal antibody (Cat # PAB12618) at 1 : 500. A major immune-reactive band is observed around ~ 150 KDa (Lane 1). This band is blocked by pre-incubation of immunizing peptide (Lane 2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CSF1R.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y723 of human CSF1R.
Sequence
DTYVEM
Host
Rabbit
Theoretical MW (kDa)
150
Reactivity
Human, Mouse
Specificity
This antibody recognizes ~150 KDa of human CSF1R at a phosphorylation site of Tyrosine 723. It does not recognize non-phosphorylated peptides.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C for three month. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The whole cell lysate derived from m-CSF stimulated LNCaP was immunoblotted by CSF1R (phospho Y723) polyclonal antibody (Cat # PAB12618) at 1 : 500. A major immune-reactive band is observed around ~ 150 KDa (Lane 1). This band is blocked by pre-incubation of immunizing peptide (Lane 2).Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSF1R
Entrez GeneID
1436Gene Name
CSF1R
Gene Alias
C-FMS, CD115, CSFR, FIM2, FMS
Gene Description
colony stimulating factor 1 receptor
Omim ID
164770Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq
Other Designations
CD115 antigen|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|soluble CSF1R variant 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The activated macrophage colony-stimulating factor (CSF-1) receptor as a predictor of poor outcome in advanced epithelial ovarian carcinoma.
Toy EP, Chambers JT, Kacinski BM, Flick MB, Chambers SK.
Gynecol Oncol 2001 Feb; 80(2):194.
Application：IHC-P, Human, Breast carcinoma, Ovarian tumor.
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The activated macrophage colony-stimulating factor (CSF-1) receptor as a predictor of poor outcome in advanced epithelial ovarian carcinoma.
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