CTNNB1 (phospho Y280) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The cell lysate derived from HeLa was immunoprobed at a dilution of 1 : 500 by the following antibodies.
1: CTNNB1 (phospho Y228) polyclonal antibody (Cat # PAB12605).
2 : CTNNB1 polyclonal antibody (Cat # PAB12659).
3 : CTNNB1 (phospho Y280) polyclonal antibody (Cat # PAB12606).
4 : CTNNB1 polyclonal antibody (Cat # PAB12660).
5 : Negative control.
Dot Blot (Peptide)
Dot Blot : 1 ug peptide was blot onto NC membrane.
A : Non-Related phosphopeptde.
B : CTNNB1 (pY280).
C : CTNNB1 (Non-Phospho).
Followed by immunoblotting CTNNB1 (phospho Y280) polyclonal antibody (Cat # PAB12606) at 1 : 1000.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CTNNB1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y280 of human CTNNB1.
Sequence
EPYGL
Host
Rabbit
Theoretical MW (kDa)
88
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~88 KDa of human CTNNB1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The cell lysate derived from HeLa was immunoprobed at a dilution of 1 : 500 by the following antibodies.
1: CTNNB1 (phospho Y228) polyclonal antibody (Cat # PAB12605).
2 : CTNNB1 polyclonal antibody (Cat # PAB12659).
3 : CTNNB1 (phospho Y280) polyclonal antibody (Cat # PAB12606).
4 : CTNNB1 polyclonal antibody (Cat # PAB12660).
5 : Negative control.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot Blot : 1 ug peptide was blot onto NC membrane.
A : Non-Related phosphopeptde.
B : CTNNB1 (pY280).
C : CTNNB1 (Non-Phospho).
Followed by immunoblotting CTNNB1 (phospho Y280) polyclonal antibody (Cat # PAB12606) at 1 : 1000. -
Gene Info — CTNNB1
Entrez GeneID
1499Gene Name
CTNNB1
Gene Alias
CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Description
catenin (cadherin-associated protein), beta 1, 88kDa
Gene Ontology
HyperlinkGene Summary
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM
Other Designations
OTTHUMP00000165222|OTTHUMP00000165223|catenin (cadherin-associated protein), beta 1 (88kD)|catenin beta-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2.
Park CS, Kim SI, Lee MS, Youn CY, Kim DJ, Jho EH, Song WK.
The Journal of Biological Chemistry 2004 Feb; 279(19):19592.
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Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2.
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