CYR61 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of cleaved CYR61 in MDA-MB-231 cell lysate using CYR61 polyclonal antibody (Cat # PAB12525). Photo courtesy of Dr. Lupu's Lab, Northwestern University. Image by Dr. Ingrid Espinoza.
Immunohistochemistry
Staining of CYR61 on human endometrium using CYR61 polyclonal antibody (Cat # PAB12525). Photo courtesy of Dr. rer. nat. Isabella Gashaw, University Duisburg-Essen.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYR61.
Immunogen
A synthetic peptide corresponding to amino acids 150-250 of human CYR61.
Host
Rabbit
Theoretical MW (kDa)
37
Reactivity
Human
Specificity
This antibody is specific to CYR61 protein.
Form
Liquid
Purification
Immunogen affinity purification
Recommend Usage
Immunocytochemistry/Immunofluorescence (1:10-1:500)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
Western Blot (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide).
Storage Instruction
Store at 4°C for short term. For long term storage, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of cleaved CYR61 in MDA-MB-231 cell lysate using CYR61 polyclonal antibody (Cat # PAB12525). Photo courtesy of Dr. Lupu's Lab, Northwestern University. Image by Dr. Ingrid Espinoza.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Staining of CYR61 on human endometrium using CYR61 polyclonal antibody (Cat # PAB12525). Photo courtesy of Dr. rer. nat. Isabella Gashaw, University Duisburg-Essen.Immunocytochemistry
Immunofluorescence
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Gene Info — CYR61
Entrez GeneID
3491Protein Accession#
O00622Gene Name
CYR61
Gene Alias
CCN1, GIG1, IGFBP10
Gene Description
cysteine-rich, angiogenic inducer, 61
Omim ID
602369Gene Ontology
HyperlinkGene Summary
CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.[supplied by OMIM
Other Designations
OTTHUMP00000012303|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61
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Interactome
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Disease
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Publication Reference
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Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium.
Gashaw I, Stiller S, Boing C, Kimmig R, Winterhager E.
Endocrinology 2008 May; 149(5):2261.
Application：IF, WB, Human , Human endometrium.
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Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium.
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