Western blot analysis of CREB1 (phospho S121) in human HEK 293T cells. Top panel : probed with CREB1 (phospho S121) polyclonal antibody (Cat # PAB12522). Bottom panel : probed with CREB antibody. Lanes 2 and 4 treated with lambda phosphatase, lanes 3 and 4 treated with 0.2mM H202.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
active transcription factor CREB,cAMP-response element-binding protein-1,transactivator protein