ALOX5 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Detection of ALOX5 in human peripheral leukocytes using ALOX5 polyclonal antibody (Cat # PAB12488) at 0.5 (Lane 1) and 2.0 ug/mL (Lane 2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALOX5.
Immunogen
A synthetic peptide corresponding to amino acids 100-200 of human ALOX5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of ALOX5 in human peripheral leukocytes using ALOX5 polyclonal antibody (Cat # PAB12488) at 0.5 (Lane 1) and 2.0 ug/mL (Lane 2). -
Gene Info — ALOX5
Entrez GeneID
240Protein Accession#
P09917Gene Name
ALOX5
Gene Alias
5-LO, 5-LOX, 5LPG, LOG5, MGC163204
Gene Description
arachidonate 5-lipoxygenase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019502|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase
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