BECN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BECN1.
Immunogen
A synthetic peptide corresponding to amino acids 1-100 of human BECN1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to human Beclin 1.
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BECN1 in mouse liver tissue lysate (50 ug) using BECN1 polyclonal antibody (Cat # PAB12472).Immunohistochemistry
Immunocytochemistry
Immunofluorescence
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Gene Info — BECN1
Entrez GeneID
8678Protein Accession#
Q14457Gene Name
BECN1
Gene Alias
ATG6, VPS30, beclin1
Gene Description
beclin 1, autophagy related
Omim ID
604378Gene Ontology
HyperlinkGene Summary
O
Other Designations
ATG6 autophagy related 6 homolog|beclin 1|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
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Interactome
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Pathway
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Disease
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Publication Reference
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Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, Codogno P.
The Journal of Biological Chemistry 2009 Jan; 284(5):2719.
Application:IP, WB, Human, HeLa, MCF-7 cells.
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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G.
Cell Metabolism 2008 May; 7(5):456.
Application:WB-Tr, Human, HEK 293 cells.
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Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus.
Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ.
The Journal of Biological Chemistry 2008 Feb; 283(8):4766.
Application:WB-Ce, Mouse, MEFs.
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A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells.
Park KJ, Lee SH, Kim TI, Lee HW, Lee CH, Kim EH, Jang JY, Choi KS, Kwon MH, Kim YS.
Cancer Research 2007 Aug; 67(15):7327.
Application:WB, Human, HC116, U87MG.
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Consequences of the selective blockage of chaperone-mediated autophagy.
Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM.
PNAS 2006 Apr; 103(15):5805.
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Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
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