Immunoblot analysis of cell lysate. HepG2 cells were transfected with wild-type or Y716F mutants of PDGF Receptor Beta. Transfected HepG2 cells were either untreated (-) or treated with PDGF-BB (+). Immunoblotting was done with PDGFRB (phospho Y716) polyclonal antibody (upper) or anti-PDGF Receptor Beta (lower).
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq