BCL2L1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of BCL2L1 expression from cell extracts with BCL2L1 polyclonal antibody (Cat # PAB12319).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : Jurkat whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo 320 whole cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of BCL2L1 on formalin fixed, paraffin embedded human intestine cancer with BCL2L1 polyclonal antibody (Cat # PAB12319).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2L1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human BCL2L1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Different to the related rat sequence by a single amino acid.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of BCL2L1 expression from cell extracts with BCL2L1 polyclonal antibody (Cat # PAB12319).
Lane 1 : MCF-7 whole cell lysate.
Lane 2 : HeLa whole cell lysate.
Lane 3 : Jurkat whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo 320 whole cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of BCL2L1 on formalin fixed, paraffin embedded human intestine cancer with BCL2L1 polyclonal antibody (Cat # PAB12319). -
Gene Info — BCL2L1
Entrez GeneID
598Gene Name
BCL2L1
Gene Alias
BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS
Gene Description
BCL2-like 1
Omim ID
600039Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq
Other Designations
OTTHUMP00000030550|OTTHUMP00000030551|OTTHUMP00000030553
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Interactome
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Pathway
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Disease
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Publication Reference
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AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.
Glushakova LG, Lisankie MJ, Eruslanov EB, Ojano-Dirain C, Zolotukhin I, Liu C, Srivastava A, Stacpoole PW.
Molecular Genetics and Metabolism 2009 Jun; 98(3):289.
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB.
Cell 1993 Aug; 74(4):597.
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AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.
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