Rabbit polyclonal antibody raised against synthetic peptide of MMP14.
A synthetic peptide corresponding to amino acids at C-terminus of human MMP14.
Human, Mouse, Rat
Different from the related mouse sequence by single amino acid.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Western Blot (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) Immunohistochemistry (Frozen sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq