CASP2 polyclonal antibody
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of CASP2 on formalin fixed, paraffin embedded human mammary cancer with CASP2 polyclonal antibody (Cat # PAB12286).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP2.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human CASP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of CASP2 on formalin fixed, paraffin embedded human mammary cancer with CASP2 polyclonal antibody (Cat # PAB12286). -
Gene Info — CASP2
Entrez GeneID
835GeneBank Accession#
BC002427Protein Accession#
AAH02427Gene Name
CASP2
Gene Alias
CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
Gene Description
caspase 2, apoptosis-related cysteine peptidase
Omim ID
600639Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
ICH-1 protease|NEDD2 apoptosis regulatory|caspase 2|neural precursor cell expressed, developmentally down-regulated 2
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Interactome
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Disease
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Publication Reference
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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
Tinel A, Tschopp J.
Science 2004 May; 304(5672):843.
Application：WB, Human, HEK 293T, Jurkat cells.
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Defects in regulation of apoptosis in caspase-2-deficient mice.
Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan J.
Genes & Development 1998 May; 12(9):1304.
Application：WB-Ti, Mouse, Ovary.
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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
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