ERBB3 (phospho Y1328) polyclonal antibody

Catalog # PAB12186

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Size:100 uL
Price: USD $ 346.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Western Blot (Cell lysate)
Application

Western Blot (Cell lysate)

Western blot analysis of extracts from HUVEC cell using ERBB3 (phospho Y1328) polyclonal antibody (Cat # PAB12186).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ERBB3 (phospho Y1328) polyclonal antibody (Cat # PAB12186).

  • Specifications

    Product Description

    Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB3.

    Immunogen

    Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1328 of human ERBB3.

    Sequence

    PDYpWH

    Host

    Rabbit

    Theoretical MW (kDa)

    185

    Reactivity

    Human, Mouse, Rat

    Specificity

    Her3/ErbB3 (phospho-Tyr1328) Antibody detects endogenous levels of Her3/ErbB3 only when phosphorylated at tyrosine 1328.

    Form

    Liquid

    Purification

    Immunoaffinity purification

    Concentration

    1 mg/mL

    Quality Control Testing

    Antibody Reactive Against Synthetic Peptide.

    Recommend Usage

    Western Blot (1:500-1:1000)
    Immunohistochemistry (1:50-1:100)
    Immunofluorescence (1:100-1:200)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

    Storage Instruction

    Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot (Cell lysate)

    Western blot analysis of extracts from HUVEC cell using ERBB3 (phospho Y1328) polyclonal antibody (Cat # PAB12186).

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ERBB3 (phospho Y1328) polyclonal antibody (Cat # PAB12186).

    Immunofluorescence

  • Gene Info — ERBB3

    Entrez GeneID

    2065

    Protein Accession#

    P21860

    Gene Name

    ERBB3

    Gene Alias

    ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3

    Gene Description

    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

    Omim ID

    190151 607598

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq

    Other Designations

    erbB-3|lethal congenital contracture syndrome 2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

  • Interactomes
  • Pathways
  • Diseases
  • Publication Reference
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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