Rabbit polyclonal antibody raised against synthetic peptide of OGG1.
A synthetic peptide corresponding to amino acids 1-100 of human OGG1.
Human, Primates, Rat
This antibody is specific to human Ogg1.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Western Blot (1:500-1:1000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000) Immunohistochemistry (Frozen sections) (1:25-1:100) The optimal working dilution should be determined by the end user.
In PBS (0.1% sodium azide)
Store at 4°C. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Immunohistochemical staining of OGG1 on formaldehyde fixed frozen sections of the substantia nigra from a Rhesus macaque with OGG1 polyclonal antibody (Cat # PAB12085). Photo courtesy of Glen Kisby, Oregon Health Sciences University. The tissue was a generous gift of Dr. Steven Kohama, Oregon National Primate Research Center.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq
8-hydroxyguanine DNA glycosylase,OTTHUMP00000122619