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Last updated: 2014/10/20
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OGG1 polyclonal antibody

  • Catalog # : PAB12085
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of OGG1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1-100 of human OGG1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Primates, Rat
  • Specificity:
  • This antibody is specific to human Ogg1.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000)
    Immunohistochemistry (Frozen sections) (1:25-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of OGG1 in HeLa and Jurkat cell lysate with OGG1 polyclonal antibody (Cat # PAB12085).
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • Western blot analysis of OGG1 of 1, 5, 10 ng titration of human recombinant Ogg1 protein with OGG1 polyclonal antibody (Cat # PAB12085).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunohistochemistry (Frozen sections)
  • Immunohistochemical staining of OGG1 on formaldehyde fixed frozen sections of the substantia nigra from a Rhesus macaque with OGG1 polyclonal antibody (Cat # PAB12085). Photo courtesy of Glen Kisby, Oregon Health Sciences University. The tissue was a generous gift of Dr. Steven Kohama, Oregon National Primate Research Center.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunohistochemistry (Frozen sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4968
  • Gene Name:
  • OGG1
  • Gene Alias:
  • HMMH,HOGG1,MUTM,OGH1
  • Gene Description:
  • 8-oxoguanine DNA glycosylase
  • Gene Summary:
  • This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq
  • Other Designations:
  • 8-hydroxyguanine DNA glycosylase,OTTHUMP00000122619
  • Gene Pathway
  • Related Disease
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