ABCA2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCA2.
Immunogen
A synthetic peptide corresponding to human ABCA2.
Sequence
C-KKQSDNLEQQETEP
Host
Goat
Theoretical MW (kDa)
270, 273
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ABCA2
Entrez GeneID
20Protein Accession#
NP_001597.2;NP_997698.1Gene Name
ABCA2
Gene Alias
ABC2, MGC129761
Gene Description
ATP-binding cassette, sub-family A (ABC1), member 2
Omim ID
600047Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family A, member 2|OTTHUMP00000064733
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Interactome
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Pathway
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Disease
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Publication Reference
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ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.
Mace S, Cousin E, Ricard S, Genin E, Spanakis E, Lafargue-Soubigou C, Genin B, Fournel R, Roche S, Haussy G, Massey F, Soubigou S, Brefort G, Benoit P, Brice A, Campion D, Hollis M, Pradier L, Benavides J, Deleuze JF.
Neurobiology of Disease 2005 Feb; 18(1):119.
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ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.
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