SPARC polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Detection of endogenous SPARC in mouse heart lysate using SPARC polyclonal antibody (Cat # PAB10384, 5 ug/mL).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPARC.
Immunogen
A synthetic peptide corresponding to human SPARC.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Detection of endogenous SPARC in mouse heart lysate using SPARC polyclonal antibody (Cat # PAB10384, 5 ug/mL).Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPARC
Entrez GeneID
6678Gene Name
SPARC
Gene Alias
ON
Gene Description
secreted protein, acidic, cysteine-rich (osteonectin)
Omim ID
182120Gene Ontology
HyperlinkGene Summary
Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM
Other Designations
cysteine-rich protein|osteonectin|secreted protein, acidic, cysteine-rich
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Interactome
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Disease
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Publication Reference
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Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
Shi Q, Bao S, Song L, Wu Q, Bigner DD, Hjelmeland AB, Rich JN.
Oncogene 2007 Jun; 26(28):4084.
Application：WB, Human, D54MG, U373MG cells.
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In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions.
Aouacheria A, Navratil V, Lopez-Perez R, Gutierrez NC, Churkin A, Barash D, Mouchiroud D, Gautier C.
BMC Genomics 2007 Jan; 8:2.
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Tissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma.
Xue LY, Hu N, Song YM, Zou SM, Shou JZ, Qian LX, Ren LQ, Lin DM, Tong T, He ZG, Zhan QM, Taylor PR, Lu N.
BMC Cancer 2006 Dec; 6:296.
Application：IHC-P, Human, Human esophageal squamous cell carcinoma.
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Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
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