S1PR1 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of lysates of McA-RH7777 cells transfected with full length human S1PR1 protein using S1PR1 polyclonal antibody (Cat # PAB10360) at 10 ug/mL (Lane 1), antibody preincubated with specific blocking peptide (Lane 2) and antibody preincubated with non-specific control peptide (Lane 3).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP4R1.
Immunogen
A synthetic peptide corresponding to C-terminus of S1PR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of lysates of McA-RH7777 cells transfected with full length human S1PR1 protein using S1PR1 polyclonal antibody (Cat # PAB10360) at 10 ug/mL (Lane 1), antibody preincubated with specific blocking peptide (Lane 2) and antibody preincubated with non-specific control peptide (Lane 3). -
Gene Info — S1PR1
Entrez GeneID
1901Gene Name
S1PR1
Gene Alias
CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, FLJ58121, S1P1
Gene Description
sphingosine-1-phosphate receptor 1
Omim ID
601974Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq
Other Designations
G protein-coupled sphingolipid receptor|OTTHUMP00000012525|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor EDG1
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension.
Toman RE, Payne SG, Watterson KR, Maceyka M, Lee NH, Milstien S, Bigbee JW, Spiegel S.
The Journal of Cell Biology 2004 Aug; 166(3):381.
Application：IF, Rat, PC-12 cells.
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Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis.
Jolly PS, Bektas M, Olivera A, Gonzalez-Espinosa C, Proia RL, Rivera J, Milstien S, Spiegel S.
The Journal of Experimental Medicine 2004 Apr; 199(7):959.
Application：WB, Rabbit, RBL-2H3 cells.
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Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor.
Dorsam G, Graeler MH, Seroogy C, Kong Y, Voice JK, Goetzl EJ.
The Journal of Immunology 2003 Oct; 171(7):3500.
Application：WB-Tr, Mouse, Rat, Th1, HTC4 cells.
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Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension.
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