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Last updated: 2014/11/23
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CIITA polyclonal antibody

  • Catalog # : PAB0658
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against full length recombinantt CIITA.
  • Immunogen:
  • Recombinant protein corresponding to full length human CIITA.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • ChIP
  • ChIP
  • ChIP results obtained with the CIITA polyclonal antibody (Cat # PAB0658). ChIP assays were performed using NALM cells (a cell line derived from human pre-B leukemia).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 4261
  • Gene Name:
  • CIITA
  • Gene Alias:
  • C2TA,CIITAIV,MHC2TA,NLRA
  • Gene Description:
  • class II, major histocompatibility complex, transactivator
  • Gene Summary:
  • This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq
  • Other Designations:
  • MHC class II transactivator type III,NLR family, acid domain containing,class II transactivator,nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
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