GAB1 (phospho Y659) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of GAB1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y659 of human GAB1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of GAB1 (phospho Y659) polyclonal antibody (Cat # PAB0477) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. -
Gene Info — GAB1
Entrez GeneID
2549Protein Accession#
NP_002030;Q13480Gene Name
GAB1
Gene Alias
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Gene Description
GRB2-associated binding protein 1
Omim ID
604439Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
Podar K, Mostoslavsky G, Sattler M, Tai YT, Hayashi T, Catley LP, Hideshima T, Mulligan RC, Chauhan D, Anderson KC.
The Journal of Biological Chemistry 2004 Mar; 279(20):21658.
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Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells.
Kapoor GS, Zhan Y, Johnson GR, O'Rourke DM.
Molecular and Cellular Biology 2004 Jan; 24(2):823.
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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
Ren Y, Meng S, Mei L, Zhao ZJ, Jove R, Wu J.
The Journal of Biological Chemistry 2003 Dec; 279(9):8497.
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Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
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