CRK (phospho S41) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CRK.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S41 of human CRK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of CRK (phospho S41) polyclonal antibody (Cat # PAB0446) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide. -
Gene Info — CRK
Entrez GeneID
1398Protein Accession#
NP_005197;Q96GA9Gene Name
CRK
Gene Alias
CRKII
Gene Description
v-crk sarcoma virus CT10 oncogene homolog (avian)
Omim ID
164762Gene Ontology
HyperlinkGene Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq
Other Designations
avian sarcoma virus CT10 (v-crk) oncogene homolog|v-crk avian sarcoma virus CT10 oncogene homolog|v-crk sarcoma virus CT10 oncogene homolog
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Interactome
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Pathway
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Publication Reference
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Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.
Bougneres L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT.
The Journal of Cell Biology 2004 Jul; 166(2):225.
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Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation.
Stoletov KV, Gong C, Terman BI.
Experimental Cell Research 2004 Apr; 295(1):258.
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Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas.
Miller CT, Chen G, Gharib TG, Wang H, Thomas DG, Misek DE, Giordano TJ, Yee J, Orringer MB, Hanash SM, Beer DG.
Oncogene 2003 Sep; 22(39):7950.
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Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.
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