TLR4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TLR4 using TLR4 polyclonal antibody (Cat # PAB0374) on (A) 0.1 ug / lane recombinant mouse TLR4 protein (tested at 2 ug/mL), (B) 20 ug / lane human intestine, and (C) 20 ug / lane mouse intestine (tested at 5 ug/mL on intestine lysates).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
Immunogen
A synthetic peptide corresponding to amino acids 100-150 of human TLR4.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TLR4 using TLR4 polyclonal antibody (Cat # PAB0374) on (A) 0.1 ug / lane recombinant mouse TLR4 protein (tested at 2 ug/mL), (B) 20 ug / lane human intestine, and (C) 20 ug / lane mouse intestine (tested at 5 ug/mL on intestine lysates).Immunoprecipitation
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Gene Info — TLR4
Entrez GeneID
7099Gene Name
TLR4
Gene Alias
ARMD10, CD284, TOLL, hToll
Gene Description
toll-like receptor 4
Omim ID
603030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
Other Designations
OTTHUMP00000022807|homolog of Drosophila toll
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Interactome
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Pathway
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Disease
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Publication Reference
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Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
Ma CY, Shi GY, Shi CS, Kao YC, Lin SW, Wu HL.
Journal of Immunology 2012 Jun; 188(12):6328.
Application：IF, IP, WB, Mouse, Mouse macrophages.
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Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.
Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H.
Journal of Immunology 2004 Sep; 173(5):3337.
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Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
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