SMAD6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SMAD6.
Immunogen
A mixture of synthetic peptides corresponding to amino acids 85-99 and 372-388 of human SMAD6 .
Sequence
RAGGPPRPMSEPGAG, NLEQRSESVRRTRSKIG
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SMAD6 in 30 ug of Jurkat cell lysate using SMAD6 polyclonal antibody (Cat # PAB0368) at 2 ug/mL . -
Gene Info — SMAD6
Entrez GeneID
4091Gene Name
SMAD6
Gene Alias
HsT17432, MADH6, MADH7
Gene Description
SMAD family member 6
Omim ID
602931Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
MAD (mothers against decapentaplegic, Drosophila) homolog 6|MAD, mothers against decapentaplegic homolog 6|Mothers against decapentaplegic, drosophila, homolog of, 6|SMAD, mothers against DPP homolog 6
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Interactome
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Pathway
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Disease
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Publication Reference
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Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue.
Frullanti E, Colombo F, Falvella FS, Galvan A, Noci S, De Cecco L, Incarbone M, Alloisio M, Santambrogio L, Nosotti M, Tosi D, Pastorino U, Dragani TA.
International Journal of Cancer 2012 Sep; 131(5):E643.
Application:WB, Human, NCI-520 cells.
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Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum.
Yoshiura S, Ohtsuka T, Takenaka Y, Nagahara H, Yoshikawa K, Kageyama R.
PNAS 2007 Jun; 104(27):11292.
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Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D.
The Journal of Biological Chemistry 2007 Jan; 282(14):10742.
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Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation.
Yamaguchi H, Zhu J, Yu T, Sasaki K, Umetsu H, Kidachi Y, Ryoyama K.
Toxicology 2006 Jun; 226(2-3):131.
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Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.
Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D.
The Journal of Biological Chemistry 2005 Nov; 281(6):3569.
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Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue.
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