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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Frozen sections)

Immunoprecipitation

Entrez GeneID

Gene Name

NLRP4

Gene Alias

CLR19.5, FLJ32126, NALP4, PAN2, PYPAF4, RNH2

Gene Description

NLR family, pyrin domain containing 4

Omim ID

Gene Ontology

Gene Summary

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM

Other Designations

NACHT, LRR and PYD containing protein 4|NACHT, leucine rich repeat and PYD containing 4|PAAD and NACHT-containing protein 2|PYRIN-containing APAF1-like protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4|