TNFRSF10B polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant TNFRSF10B.
Immunogen
Recombinant protein corresponding to amino acids 388-407 (isoform 2) of human TNFRSF10B.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 20 ug of whole cell lysates from HL-60 cells with TNFRSF10B polyclonal antibody (Cat # PAB0155) at 5 ug/mL dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunofluorescence
Flow Cytometry
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Gene Info — TNFRSF10B
Entrez GeneID
8795Gene Name
TNFRSF10B
Gene Alias
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Gene Description
tumor necrosis factor receptor superfamily, member 10b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq
Other Designations
Fas-like protein|OTTHUMP00000123492|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d
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Interactome
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Pathway
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Disease
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Publication Reference
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Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.
Kusaba M, Nakao K, Goto T, Nishimura D, Kawashimo H, Shibata H, Motoyoshi Y, Taura N, Ichikawa T, Hamasaki K, Eguchi K.
Journal of Hepatology 2007 Jun; 47(4):546.
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Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapy.
Xu J, Zhou JY, Wu GS.
Cancer Research 2006 Oct; 66(20):10092.
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Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Song JH, Bellail A, Tse MC, Yong VW, Hao C.
Journal of Neuroscience 2006 Mar; 26(12):3299.
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Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma.
Younes M, Georgakis GV, Rahmani M, Beer D, Younes A.
European Journal of Cancer 2006 Jan; 42(4):542.
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3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.
Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S.
Carcinogenesis 2005 Dec; 27(4):717.
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Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death.
Georgios V Georgakis, Yang Li, Robin Humphreys, Michael Andreeff, Susan O'Brien, Mamoun Younes, Antonino Carbone, Vivian Albert, Anas Younes.
British Journal of Haematology 2005 Aug; 130(4):501.
Application:Flow Cyt, ICC, IHC-P, WB-Ce, WB-Ti, Human, HD-LM2, HD-MyZ, Jeko-1, Jurkat, Karpas299, KM-H2, L-428, SP53, SUDHL1 cells, Human primary lymphoma cells, Human lymphoma tissues.
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c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
Wei Zou, Xiangguo Liu, Ping Yue, Zhongmei Zhou, Michael B Sporn, Reuben Lotan, Fadlo R Khuri, Shi-Yong Sun.
Cancer Research 2004 Oct; 64(20):7570.
Application:Flow Cyt, WB-Ce, WB-Tr, Human, A-549, H157, H1792 cells.
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Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo.
Qing-Lin Fan, Wen-Yi Zou, Li-Hua Song, Wei Wei.
Cancer Chemotherapy and Pharmacology 2005 Feb; 55(2):189.
Application:WB-Ce, Human, A-549 cells.
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Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.
Zhaoyu Jin, E Robert McDonald 3rd, David T Dicker, Wafik S El-Deiry.
The Journal of Biological Chemistry 2004 Aug; 279(34):35829.
Application:IF, WB-Ce, Human, SW480 cells.
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Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
K Kim, H Nakagawa, P Fei, A K Rustgi, W S El-Deiry.
Cell Death and Differentiation 2004 May; 11(5):583.
Application:WB-Ce, Human, EPC2, HCE4, HCE7, TE2, TE3, TE5, TE7, TE8, TE9 cells.
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The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation.
Tiziana Dandrea, Heike Hellmold, Carina Jonsson, Boris Zhivotovsky, Tim Hofer, Lars Wärngård, Ian Cotgreave.
Free Radical Biology & Medicine 2004 Apr; 36(7):881.
Application:WB-Ce, Human, A-549 cells.
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Flow cytometric measurement of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Helicobacter pylori-associated gastritis.
Shohei Koyama.
Journal of Gastroenterology and Hepatology 2003 Jul; 18(7):763.
Application:Flow Cyt, Human, Human gastric mucosal epithelium, Human mucosal lymphocytes.
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Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Karthikeyan Kandasamy, Srinivasa M Srinivasula, Emad S Alnemri, Craig B Thompson, Stanley J Korsmeyer, Joseph L Bryant, Rakesh K Srivastava.
Cancer Research 2003 Apr; 63(7):1712.
Application:WB-Tr, Mouse, MEFs.
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Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL).
Manal A Eid, Ronald W Lewis, M Vijay Kumar.
Molecular Cancer Therapeutics 2002 Aug; 1(10):831.
Application:WB-Ce, Human, Mouse, LNCaP, LNCaP C4-2 cells.
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Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver.
Huang-Ge Zhang, Jinfu Xie, Liang Xu, Pingar Yang, Xin Xu, Sheher Sun, Yongming Wang, David T Curiel, Hui-Chen Hsu, John D Mountz.
Journal of Virology 2002 Jun; 76(11):5692.
Application:ELISA, Human, HEK 293 cells.
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Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor.
Koyama S, Koike N, Adachi S.
Journal of Cancer Research and Clinical Oncology 2002 Feb; 128(2):73.
Application:Flow Cyt, Human, Stomach carcinoma, Tumor infiltrating lymphocytes.
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Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.
Burns TF, Bernhard EJ, El-Deiry WS.
Oncogene 2001 Aug; 20(34):4601.
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Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
Cuello M, Ettenberg SA, Clark AS, Keane MM, Posner RH, Nau MM, Dennis PA, Lipkowitz S.
Cancer Research 2001 Jun; 61(12):4892.
Application:Flow Cyt, WB-Ce, Human, SKBr-3, SKOv-3, MDA-MB-231 cells.
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The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein.
Basile JR, Zacny V, Munger K.
The Journal of Biological Chemistry 2001 Jun; 276(25):22522.
Application:WB-Tr, Human, HFKs.
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Molecular determinants of response to TRAIL in killing of normal and cancer cells.
K Kim, M J Fisher, S Q Xu, W S el-Deiry.
Clinical Cancer Research 2000 Feb; 6(2):335.
Application:WB-Ce, Human, HS27, WI38 cells.
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Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.
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