PRKCG (Human) Recombinant Protein
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Specification
Product Description
Human PRKCG (NM_002739.3, 1 a.a. - 697 a.a.) full-length recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
112.289
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
One-step affinity purification using GSH agarose
Concentration
0.088 ug/uL
Activity
325 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — PRKCG
Entrez GeneID
5582Protein Accession#
NM_002739.3Gene Name
PRKCG
Gene Alias
MGC57564, PKC-gamma, PKCC, PKCG, SCA14
Gene Description
protein kinase C, gamma
Gene Ontology
HyperlinkGene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq
Other Designations
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Publication Reference
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HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia.
Garzon J, Herrero-Labrador R, Rodriguez-Munoz M, Shah R, Vicente-Sanchez A, Wagner CR, Sanchez-Blazquez P.
Neuropharmacology 2015 Feb; 89:412.
Application:Func, Mouse, Recombinant proteins.
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GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.
Sánchez-Blázquez P, Rodríguez-Muñoz M, Bailón C, Garzón J.
Antioxidants & Redox Signaling 2012 Nov; 17(9):1163.
Application:WB-Tr, Mouse, Brain.
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HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia.
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