FGR (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
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Specification
Product Description
Human FGR (NM_005248.1, 1 a.a. - 529 a.a.) full-length recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
93.934
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
One-step affinity purification using GSH-agarose
Concentration
0.055 ug/uL
Activity
16 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — FGR
Entrez GeneID
2268Protein Accession#
NM_005248.1Gene Name
FGR
Gene Alias
FLJ43153, MGC75096, SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr
Gene Description
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Omim ID
164940Gene Ontology
HyperlinkGene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000003601|OTTHUMP00000003602|OTTHUMP00000003603|c-fgr protooncogene|c-src-2 proto-oncogene|p55-c-fgr protein|proto-oncogene tyrosine-protein kinase FGR
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