IL16 (Human) Recombinant Protein
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Specification
Product Description
Human IL16 (AAC12732) recombinant protein expressed in Escherichia coli.
Sequence
MPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS
Host
Escherichia coli
Theoretical MW (kDa)
13.5
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the ability to chemoattract human T lymphocytes and is detectable starting at 5 ng/mL.
Quality Control Testing
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue
Lane 1: non-reducing conditions
Lane 2: reducing conditionsStorage Buffer
Lyophilized 10 mM Na2PO4, pH 7.5.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IL16
Entrez GeneID
3603Protein Accession#
AAC12732Gene Name
IL16
Gene Alias
FLJ16806, FLJ42735, FLJ44234, HsT19289, IL-16, LCF, prIL-16
Gene Description
interleukin 16 (lymphocyte chemoattractant factor)
Omim ID
603035Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000190849|OTTHUMP00000190850|interleukin 16|lymphocyte chemoattractant factor
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