APOE (Human) Native Protein
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Specification
Product Description
Human APOE native protein from human plasma.
Host
Human
Theoretical MW (kDa)
34
Form
Lyophilized
Preparation Method
Native protein purified from human plasma
Purity
>= 95% by SDS-PAGE
Storage Buffer
In 50 mM NH4HCO3, pH 8.0.
It is recommended to reconstitute 25 µg of the protein with 0.05 ml of reagent grade water to 0.5 mg/ml.Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — APOE
Entrez GeneID
348Gene Name
APOE
Gene Alias
AD2, LPG, MGC1571, apoprotein
Gene Description
apolipoprotein E
Gene Ontology
HyperlinkGene Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq
Other Designations
apolipoprotein E3
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Interactome
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Disease
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