Human TNFRSF10B (O14763, 133 amino acids) partial recombinant protein expressed in Escherichia coli.
Theoretical MW (kDa):
Escherichia coli expression system
>= 98% by SDS-PAGE and HPLC
< 0.1 ng/ug
Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L.50% inhibition (100 ng/mL of sTRAIL/Apo2L) was reached using a concentration of 1000 ng/mL of sTRAIL Receptor-2.
Store at -20°C on dry atmosphere. After reconstitution with sterilized water, store at -20°C. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq