Mouse monoclonal antibody raised against full length recombinant PDGFRB.
Recombinant protein corresponding to full length human PDGFRB.
Theoretical MW (kDa):
The monoclonal antibody 18A2 recognizes PDGFRB (CD140b), the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
Size-exclusion chromatography purification
Flow Cytometry (20 uL reagent/100 uL of whole blood or 106 cells) The optimal working dilution should be determined by the end user.
In PBS, pH 7.4 (0.02% BSA, 15 mM sodium azide)
Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq