Formalin-fixed and paraffin-embedded human tonsil tissue (A, 4 µm), human colon adenocarcinoma (B, 4 µm), and human liver tissue (C, 4 µm), stained with KRT19 monoclonal antibody, clone E16-L (Cat # MAB9770) shows strong positive cytoplasmic immunostaining of the squamous epithelial cells (A), strong positive cytoplasmic immunostaining of the neoplastic cells (B), and positive cytoplasmic immunostaining of the bile duct epithelial cells (C). Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq
40-kDa keratin intermediate filament,cytokeratin 19,keratin, type I cytoskeletal 19,keratin, type I, 40-kd