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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human liver tissue (A, 4 µm), and skin tissue with neuroendokrine carcinoma of skin- Merkel cell carcinoma (B, 4 µm), stained with KRT18 monoclonal antibody, clone R20-H (Cat # MAB9769) shows strong positive cytoplasmic immunostaining of the bile duct epithelial cells and week to moderate stains of liver cells (A), strong positive cytoplasmic and dot-like immunostaining of neoplastic cells (B).
Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.

Immunohistochemistry (Frozen sections)

Entrez GeneID

3875

Protein Accession#

P05783

Gene Name

KRT18

Gene Alias

CYK18, K18

Gene Description

keratin 18

Omim ID

148070 215600

Gene Ontology

Hyperlink

Gene Summary

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

cell proliferation-inducing protein 46|cytokeratin 18