Formalin-fixed and paraffin-embedded human liver tissue (A, 4 µm), and skin tissue with neuroendokrine carcinoma of skin- Merkel cell carcinoma (B, 4 µm), stained with KRT18 monoclonal antibody, clone R20-H (Cat # MAB9769) shows strong positive cytoplasmic immunostaining of the bile duct epithelial cells and week to moderate stains of liver cells (A), strong positive cytoplasmic and dot-like immunostaining of neoplastic cells (B). Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
cell proliferation-inducing protein 46,cytokeratin 18