BUB1B monoclonal antibody, clone P10.8G1.G11.H12
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis in K562 and HeLa cells were separated according to their position in the cell cycle by centrifugal elutriation. BUB1B was immunoprecipitated from equal amouts of protein from each fraction, and then tested for autokinase activity (top) or probed with BUB1B antibodies to compare its cell cycle expression profile (middle and bottom). with BUB1B monoclonal antibody, clone P10.8G1.G11.H12 (Cat # MAB8964).
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Specification
Product Description
Mouse monoclonal antibody raised against BUB1B.
Amount
100 uL
Immunogen
Recombinant protein corresponding to human BUB1B.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Purified ascites
Concentration
1 ug/uL
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis in K562 and HeLa cells were separated according to their position in the cell cycle by centrifugal elutriation. BUB1B was immunoprecipitated from equal amouts of protein from each fraction, and then tested for autokinase activity (top) or probed with BUB1B antibodies to compare its cell cycle expression profile (middle and bottom). with BUB1B monoclonal antibody, clone P10.8G1.G11.H12 (Cat # MAB8964).Immunofluorescence
Immunoprecipitation
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Gene Info — BUB1B
Entrez GeneID
701Gene Name
BUB1B
Gene Alias
BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1
Gene Description
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
Gene Ontology
HyperlinkGene Summary
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq
Other Designations
BUB1 budding uninhibited by benzimidazoles 1 homolog beta|MAD3/BUB1-related protein kinase|budding uninhibited by benzimidazoles 1, beta
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Interactome
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Pathway
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Disease
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