Products

Western Blot (Cell lysate)

Western blot analysis of ABCA1 induction by cholesterol (+) in human fibroblast cells from different patients (1, 2, 3, 4). Simultaneous bloting with anti-actin antibody was used for protein loading control.

Immunohistochemistry

Immunoprecipitation

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

19

Gene Name

ABCA1

Gene Alias

ABC-1, ABC1, CERP, FLJ14958, HDLDT1, MGC164864, MGC165011, TGD

Gene Description

ATP-binding cassette, sub-family A (ABC1), member 1

Omim ID

143890 205400 600046 604091

Gene Ontology

Hyperlink

Gene Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq

Other Designations

ATP binding cassette transporter 1|ATP-binding cassette 1|ATP-binding cassette, sub-family A member 1|OTTHUMP00000021833|cholesterol efflux regulatory protein|membrane-bound