HSPA5 monoclonal antibody
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant HSPA5.
Immunogen
Recombinant protein corresponding to C-terminus residues of human HSPA5.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to HSPA5.
Form
Liquid
Purification
Protein G purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:100-1:2000)
ELISA (1:5000-1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of HSPA5 monoclonal antibody (Cat # MAB8736) at 1 : 2000 dilution interacts with recombinant HSPA5 protein with a DsbA tag. Predicted band size : 48 KDa. Observed band size : 48 KDa.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSPA5
Entrez GeneID
3309Gene Name
HSPA5
Gene Alias
BIP, FLJ26106, GRP78, MIF2
Gene Description
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Omim ID
138120Gene Ontology
HyperlinkGene Summary
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
Other Designations
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD)|OTTHUMP00000022124|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|heat shock 70kDa protein 5
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Interactome
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Publication Reference
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Radioprotective effects of genistein on HL-7702 cells via the inhibition of apoptosis and DNA damage.
Song L, Ma L, Cong F, Shen X, Jing P, Ying X, Zhou H, Jiang J, Yan H.
Cancer Letters 2015 Sep; 366(1):100.
Application:WB, Human, Embryo liver L-02 cells.
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Radioprotective effects of genistein on HL-7702 cells via the inhibition of apoptosis and DNA damage.
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