IL1A monoclonal antibody, clone 1F3B3
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant IL1A.
Immunogen
Recombinant protein corresponding to human IL1A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using IL1A monoclonal antibody, clone 1F3B3 (Cat # MAB8312) against trucated IL1A recombinant protein.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL1A
Entrez GeneID
3552Gene Name
IL1A
Gene Alias
IL-1A, IL1, IL1-ALPHA, IL1F1
Gene Description
interleukin 1, alpha
Omim ID
147760Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq
Other Designations
IL1A (IL1F1)|hematopoietin-1|preinterleukin 1 alpha|pro-interleukin-1-alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.
Du Y, Dodel RC, Eastwood BJ, Bales KR, Gao F, Lohmuller F, Muller U, Kurz A, Zimmer R, Evans RM, Hake A, Gasser T, Oertel WH, Griffin WS, Paul SM, Farlow MR.
Neurology 2000 Aug; 55(4):480.
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Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.
Grimaldi LM, Casadei VM, Ferri C, Veglia F, Licastro F, Annoni G, Biunno I, De Bellis G, Sorbi S, Mariani C, Canal N, Griffin WS, Franceschi M.
Annals of Neurology 2000 Mar; 47(3):361.
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Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.
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