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Last updated: 2014/9/1
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CASP3 monoclonal antibody, clone SB71b1 (5G5A11)

  • Catalog # : MAB8216
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant CASP3.
  • Immunogen:
  • Recombinant protein corresponding to human CASP1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Western Blot (1-5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 100 mM BBS, pH 8.0
  • Storage Instruction:
  • Store at 4°C.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Jurkat cells stimulated with (Lane 1) or without (Lane 2) anti-DR5 antibody. Cell lysate wasstained with CASP3 monoclonal antibody, clone SB71b1 (5G5A11) (Cat # MAB8216)-HRP at a 1 :1000 dilution.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 836
  • Gene Name:
  • CASP3
  • Gene Alias:
  • CPP32,CPP32B,SCA-1
  • Gene Description:
  • caspase 3, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related cysteine protease,cysteine protease CPP32,procaspase3
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