CASP2 monoclonal antibody, clone SB123a
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rat monoclonal antibody raised against native CASP2.
Immunogen
Native purified human CASP2.
Host
Rat
Reactivity
Human
Form
Liquid
Isotype
IgM
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.0
Storage Instruction
Store at 4°C.
-
Applications
Western Blot (Cell lysate)
Jurkat cells stimulated with anti-DR5antibody. Cell lysate was stained with CASP2 monoclonal antibody, clone SB123a (Cat # MAB8215). HRP-conjugatedGoat anti-Rat IgM was used to develop. -
Gene Info — CASP2
Entrez GeneID
835Gene Name
CASP2
Gene Alias
CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
Gene Description
caspase 2, apoptosis-related cysteine peptidase
Omim ID
600639Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
ICH-1 protease|NEDD2 apoptosis regulatory|caspase 2|neural precursor cell expressed, developmentally down-regulated 2
-
Interactome
-
Disease
-
Publication Reference
-
The enigma of caspase-2: the laymen's view.
Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A.
Cell Death and Differentiation 2008 Nov; 16(2):195.
-
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A.
The Journal of Cell Biology 2002 Apr; 157(3):455.
-
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
Janicke RU, Sprengart ML, Wati MR, Porter AG.
The Journal of Biological Chemistry 1998 Apr; 273(16):9357.
-
The enigma of caspase-2: the laymen's view.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com