EPCAM monoclonal antibody, clone AUA1
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Specification
Product Description
Mouse monoclonal antibody raised against native EPCAM.
Immunogen
Native purified from human LoVo cell line.
Host
Mouse
Reactivity
Human
Specificity
EpCAM (AUA1).
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — EPCAM
Entrez GeneID
4072Gene Name
EPCAM
Gene Alias
17-1A, 323/A3, CD326, CO-17A, CO17-1A, EGP, EGP-2, EGP34, EGP40, ESA, Ep-CAM, GA733-2, HEA125, KS1/4, KSA, M4S1, MH99, MIC18, MK-1, MOC31, TACST-1, TACSTD1, TROP1, hEGP-2
Gene Description
epithelial cell adhesion molecule
Omim ID
185535Gene Ontology
HyperlinkGene Summary
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq
Other Designations
adenocarcinoma-associated antigen|carcinoma-associated antigen GA733-2|human epithelial glycoprotein-2|membrane component, chromosome 4, surface marker (35kD glycoprotein)|tumor-associated calcium signal transducer 1
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Interactome
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Disease
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Publication Reference
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Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions.
Epenetos AA, Canti G, Taylor-Papadimitriou J, Curling M, Bodmer WF.
Lancet (London, England) 1982 Nov; 2(8306):1004.
Application：IHC, Human, Smears of cells from serous effusions.
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Detection of human cancer in an animal model using radio-labelled tumour-associated monoclonal antibodies.
Epenetos AA, Nimmon CC, Arklie J, Elliott AT, Hawkins LA, Knowles RW, Britton KE, Bodmer WF.
British Journal of Cancer 1982 Jul; 46(1):1.
Application：Func, IHC-P, Human, HT-29 cells, HT-29 tumors.
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Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions.
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