ERBB4 monoclonal antibody, clone HFR1
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of ERBB4 detected in human brain lysates using ERBB4 monoclonal antibody, clone HFR1 (Cat # MAB7170) at 2.0 ug/mL .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ERBB4.
Immunogen
A synthetic peptide corresponding to amino acids 1250-1264 of human ERBB4.
Sequence
RSTLQHPDYLQEYST
Host
Mouse
Reactivity
Human, Mouse
Specificity
HER4 (HFR1). Predicted to react with Rat (100% identity with immunogen) and Chicken (100% identity with immunogen) due to sequence homology.T his antibody is useful for Western blot analysis (predicted molecular weight 147 KDa). There may be some non-specific staining below 50 KDa.
Form
Liquid
Isotype
IgG2b
Recommend Usage
Western Blot (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (1 mg/mL BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of ERBB4 detected in human brain lysates using ERBB4 monoclonal antibody, clone HFR1 (Cat # MAB7170) at 2.0 ug/mL .Immunohistochemistry
Immunoprecipitation
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Gene Info — ERBB4
Entrez GeneID
2066Gene Name
ERBB4
Gene Alias
HER4, MGC138404, p180erbB4
Gene Description
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Omim ID
600543Gene Ontology
HyperlinkGene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4|v-erb-a erythroblastic leukemia v
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Interactome
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Pathway
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Disease
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