PTPRC monoclonal antibody, clone C11
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Specifications
Product Description
Mouse monoclonal antibody raised against native PTPRC.
Immunogen
Native purified PTPRC from peripheral blood mononuclear cells.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — PTPRC
Entrez GeneID
5788Gene Name
PTPRC
Gene Alias
B220, CD45, CD45R, GP180, LCA, LY5, T200
Gene Description
protein tyrosine phosphatase, receptor type, C
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|glycoprotein|leukocyte-common antigen|protein tyrosine phosphatase, receptor type, c polypeptide
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Interactomes
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Pathways
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Diseases
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Publication Reference
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The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
Leitenberg D, Novak TJ, Farber D, Smith BR, Bottomly K.
The Journal of Experimental Medicine 1996 Jan; 183(1):249.
Application:Flow Cyt, Mouse, BW cells.
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CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development.
Trowbridge IS, Thomas ML.
Annual Review of Immunology 1994 Jan; 12:85.
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Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes.
Dianzani U, Redoglia V, Malavasi F, Bragardo M, Pileri A, Janeway CA Jr, Bottomly K.
Eur J Immunol 1992 Feb; 22(2):365.
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The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
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