ABCC12 monoclonal antibody, clone M9I-38
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Specification
Product Description
Rat monoclonal antibody raised against partial recombinant ABCC12.
Immunogen
Recombinant protein corresponding to amino acids 1-42 of human ABCC12.
Host
Rat
Reactivity
Human
Specificity
M9I-38 reacts with an internal epitope of MRP9 (ABCC12), an approximately 150 kD transmembrane protein that is related to the multidrug resistance protein MRP1.
Form
Liquid
Isotype
IgG
Recommend Usage
Immunohistochemistry (Frozen sections) (1:20)
Immunocytochemistry (1:20-1:50)
Wstern Blot (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum-free culture supernatant (0.7% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — ABCC12
Entrez GeneID
94160Gene Name
ABCC12
Gene Alias
MGC27071, MRP9
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Omim ID
607041Gene Ontology
HyperlinkGene Summary
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq
Other Designations
ATP-binding cassette protein C12|ATP-binding cassette transporter sub-family C member 12|OTTHUMP00000164186|multidrug resistance-associated protein 9
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Pathway
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Disease
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Publication Reference
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Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.
The Biochemical Journal 2007 Aug; 406(1):31.
Application：ICC, IF, IHC, WB-Tr, Human, Mouse, HEK 293 cells, Mouse sperm, testis.
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ABCC10, ABCC11, and ABCC12.
Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Archiv 2007 Feb; 453(5):675.
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MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I.
PNAS 2002 May; 99(10):6997.
Application：WB-Ti, Human, Testis.
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Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
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