ABCC10 monoclonal antibody, clone M7I-3
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Specification
Product Description
Rat monoclonal antibody raised against partial recombinant ABCC10.
Immunogen
Recombinant protein corresponding to amino acids 194-272 of human ABCC10.
Host
Rat
Reactivity
Human
Specificity
M7I-3 reacts with an internal epitope of MRP7 (ABCC10), an approximately 160 kD transmembrane protein that is related to the multidrug resistance protein MRP1.
Form
Liquid
Isotype
IgG
Recommend Usage
Immunohistochemistry (Frozen sections) (1:20)
Immunocytochemistry (1:20-1:50)
Wstern Blot (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum-free culture supernatant (0.7% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — ABCC10
Entrez GeneID
89845Gene Name
ABCC10
Gene Alias
EST182763, MRP7, SIMRP7
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 10|multidrug resistance-associated protein 7
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Interactome
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Pathway
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Publication Reference
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Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10).
Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK, Hopper-Borge E, Ouyang J, Chen ZS.
PLoS One 2009 Oct; 4(10):e7520.
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ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer.
Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, Maeno K, Sato S, Ueda R.
Oncology Reports 2009 Jan; 21(1):263.
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Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B.
Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD.
Cancer Research 2009 Jan; 69(1):178.
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Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10).
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