COL2A1 monoclonal antibody, clone II-4C11
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Specification
Product Description
Mouse monoclonal antibody raised against native COL2A1.
Immunogen
Native purified human COL2A1.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts specifically with human costal cartilage type II collagen.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-10 ug/mL)
Immunohistochemistry (Frozen sections) (1-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM sodium phosphate buffer, pH 7.0 (1% protease-free BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — COL2A1
Entrez GeneID
1280Gene Name
COL2A1
Gene Alias
ANFH, AOM, COL11A3, MGC131516, SEDC
Gene Description
collagen, type II, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000195063|cartilage collagen|chondrocalcin|collagen II, alpha-1 polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Collagen heterogeneity in human cartilage: identification of several new collagen chains.
Burgeson RE, Hollister DW.
Biochemical and Biophysical Research Communications 1979 Apr; 87(4):1124.
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Collagen heterogeneity in human cartilage: identification of several new collagen chains.
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