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Last updated: 2014/12/21
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CTNNB1 monoclonal antibody, clone EM-22

  • Catalog # : MAB6470
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant CTNNB1.
  • Immunogen:
  • Recombinant protein corresponding to human CTNNB1.
  • Host:
  • Mouse
  • Reactivity:
  • Hamster, Human, Mouse
  • Specificity:
  • This antibody reacts with C-terminal part of beta-catenin, an 88 KDa multi functional protein involved both in cell adhesion and in activation of transcription.
  • Form:
  • Liquid
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blotting analysis of beta-catenin in murine 3T3 (Lane 1), C57 (Lane 2) and KW1 (Lane 3) cell lines using CTNNB1 monoclonal antibody, clone EM-22 (Cat # MAB6470).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining of beta-catenin in (human colon adenocarcinoma cell line) HT29 using CTNNB1 monoclonal antibody, clone EM-22 (Cat # MAB6470) (green). Cell nuclei visualized by DAPI (blue).
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometry analysis (intracellular) of beta-catenin in human MCF-7 cell line by CTNNB1 monoclonal antibody, clone EM-22-Alexa Fluor® 488 (red) compared to isotype control (blue).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 1499
  • Gene Name:
  • CTNNB1
  • Gene Alias:
  • CTNNB,DKFZp686D02253,FLJ25606,FLJ37923
  • Gene Description:
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • Gene Summary:
  • Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM
  • Other Designations:
  • OTTHUMP00000165222,OTTHUMP00000165223,catenin (cadherin-associated protein), beta 1 (88kD),catenin beta-1
  • Interactome
  • Interactome
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